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N-A-C for Depression and Anxiety

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Why are people depressed and anxious?

Anxiety and other mental challenge have two components – physical and psychological. (This is a false dichotomy, as you’ll soon understand.)

The psychological components of anxiety come from cultural brainwashing. Most of the “problems” we have in the West were taught to us. For example people feel anxious about growing old. In other cultures age and wisdom are celebrated. Some people obsess over their looks, becoming depressed when they lose them, and fail to build character.

Shame is the only sin in the modern West.

We are also taught to let haters control us. For example, any article about a supplement – even one that is clinically proven – will be met with nasty comments.

  • “Hey gorilla man is selling supplements.” (I don’t sell N-A-C.)
  • “There’s no such things as toxins!” (False. Run a PubMed search for “oxidative stress,” and its causes.)
  • “Snake oil!” (N-A-C is well-studied, and is the opposite of an unproven or ineffective product.)

People often refuse to take action because they are afraid of what haters will say. When you refuse to take action to improve your life, you continue the spiral of depression and anxiety, because you’re not living the life YOU want to live.

Mindset training gets you past the societal bullsh-t, but there is an actual physiological basis for many depressive mental conditions.

Could mental illness be caused by oxidative stress?

Top clinicians and researchers are exploring the role role oxidative stress plays in mental illness. There are several studies to peruse on PubMed.

A Meta-Analysis of Oxidative Stress Markers in Depression (PubMed):

Studies have suggested that depression was accompanied by oxidative stress dysregulation, including abnormal total antioxidant capacity (TAC), antioxidants, free radicals, oxidative damage and autoimmune response products. This meta-analysis aims to analyse the clinical data quantitatively by comparing the oxidative stress markers between depressed patients and healthy controls.

There’s more.

See, Is depression associated with increased oxidative stress?

A systematic review and meta-analysis. (“This meta-analysis finds that oxidative stress, as measured by 8-OHdG and F2-isoprostanes, is increased in depression. Larger-scale studies are needed to extend the evidence on oxidative stress in depression, and examine the potential impact of treatment.”)

And, The efficacy of adjunctive N-acetylcysteine in major depressive disorder: a double-blind, randomized, placebo-controlled trial (PubMed.)

These data implicate the pathways influenced by NAC in depression pathogenesis, principally oxidative and inflammatory stress and glutamate, although definitive confirmation remains necessary.”)

See also, The Glutathione System: A New Drug Target in Neuroimmune Disorders (PudMed.)

Glutathione depletion and concomitant increase in oxidative and neurological stress and mitochondrial dysfunctions play a role in the pathophysiology of diverse neuroimmune disorders, including depression, myalgic encephalomyelitis/chronic fatigue syndrome and Parkinson’s disease, suggesting that depleted GSH is an integral part of these diseases.”

On and on it goes.

 Markers of Oxidative Stress and Neuroprogression in Depression Disorder (PubMed).

Oxidative stress plays significant role in pathophysiology of major depression via actions of free radicals, nonradical molecules, and reactive oxygen and nitrogen species

The research is ongoing, of course, but when I found it, the choice to try a $15 a month supplement was a no-brainer.

N-A-C changed my life. I haven’t had anything close to an “anxiety attack,” despite attacks on me that would crush 99.99% of other people, in over a decade.

N-Acetylcysteine (N-A-C) has been clinically proven to help treat symptoms of anxiety, depression, and bipolar.

N-Acetylcysteine is a powerful nootropic with still many unstudied benefits. N-A-C has been used by visionary doctors to help treat intractable depression and anxiety.

Why haven’t you heard about the magical effects of N-A-C? Simple. Go on Amazon and see how much a bottle of N-A-C costs. There’s no profit in this stuff, even though there is solid science supporting its use.

According to N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action (PubMed):

There is a growing body of literature exploring the use of NAC in the treatment of psychiatric illness. There is provisional evidence of the potential benefit of NAC in a wide range of disorders. Many of these disorders have limited treatment options or suboptimal outcomes with current treatments.

See, N-acetyl cysteine for depressive symptoms in bipolar disorder–a double-blind randomized placebo-controlled trial (“NAC appears a safe and effective augmentation strategy for depressive symptoms in bipolar disorder.”) (PubMed.)

See also, N-acetyl cysteine as a glutathione precursor for schizophrenia–a double-blind, randomized, placebo-controlled trial. (“These data suggest that adjunctive NAC has potential as a safe and moderately effective augmentation strategy for chronic schizophrenia.”) (PubMed.)

Why does N-A-C help treat depression?

Acetylcysteine is a glutathione precursor, which means acetylcysteine is converted into glutathione.

Glutathione is an antioxidant that used by your to reduce oxidative stress. Oxidative stress is associated with depression, anxiety, and other more severe conditions.

See, Invivo antioxidant status: a putative target of antidepressant action (PubMed):

Oxidative stress is a critical route of damage in various psychological stress-induced disorders, such as depression.

How much N-A-C should you take?

That would be medical advice, which I don’t give. However, participants in the studies usually used between 1 and 2 grams daily.

I personally take 2 grams a day of time-released NAC

What brand of N-A-C is best?

I personally use Jarrow’s form of N-A-C Sustain, which is time released.

Do you sell N-A-C?

No. Although N-A-C is a must-have product for me, it’s inexpensive. It’d cost me more to private label and deal with the logistics of selling it than it would bring in profit.

Also, Gorilla Mind is a separate company that I invested in. Gorilla Mind has fantastic products, but this isn’t a plug for any of them.

This is a plug for N-A-C.

And if you do like this article, sign up to receive more like it for free.

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Mindset

Blood Work for Men

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Women live longer than men because women go to the doctor. Sure there is more to it than that, but it’s also true that if a woman sees a mole or something, she’s calling the dermatologist. Men accept “aches and pains” as sign they are growing old and never see a doctor until it’s too late.

Part of taking care of yourself is getting regular blood work done (at least once a year) and knowing how to read your own blood work. The most important tests for men health are testosterone levels, cholesterol levels, fasting glucose levels, and Vitamin D.

  • As always, never undergo a diet or exercise regime without a doctor’s supervision!

Yes, you have to learn how to read your own labs because most doctors won’t order the full male anti-aging lab work you need (insurance companies often won’t cover a full panel), and if when doctors do order full labs, they only look to see if you’re with “range.”

Take testosterone levels for example. My own recent blood works shows I am within range, and even have a healthy overall testosterone level. But I’m at the bottom 20% percentile for free testosterone. (Isn’t it funny that people often accuse me of having ‘roid rage. I’m actually low T!)

Let’s go into my own blood work.

Testosterone levels.

Here is what the lab work looks like. Does it sound confusing? Fret not.

This testosterone lab result shows my testosterone levels are 538.8 ng/dL.

500 ng/DL is considered a healthy level by most general physicians who tell you to eat according to the Food Pyramid. It’s also the magic number to get TRT.

  • See, “Testosterone Replacement Therapy: Playing Catch-up With Patients
  • Although there is no consensus on an absolute number that defines a low testosterone level, concern exists that there are economic incentives to raise the bar for normal and thereby increase the potential market for testosterone-raising products. Many commercial avenues for the treatment of low T do not follow the standards of the established medical community. Some websites suggest screening for low T with total and free testosterone levels for all men aged > 40 years. Others advise men to consider TRT if they have a total testosterone level of < 500 ng/dL or a free testosterone level that is not in the upper one-third range for men aged 21 to 49 years.

Even though my testosterone is within the average range, but the biological marker that matters is free testosterone.

  • Free Testosterone(Direct) 9.5 NORMAL

The range for free testosterone is 6.8-21.5 pg/mL. A level of 9.5 pg/mL is in the low range of testosterone.

Of course if you go to the doctor and get labs ordered, it’s unlikely he or she will even order a test for free testosterone.

And unless you ask for your results, the doctor is only going to look to see if you’re within range.

You can have low testosterone or have other issues even if you’re within range.

Cholesterol levels.

The scientific consensus on cholesterol levels and heart attack risk is a mess. First they said high cholesterol would lead to a heart attack. Then they said your HDL (high density lipoprotein) levels should be used to offset your overall levels. Now…. They don’t know.

Here is the latest on cholesterol and heart attack risk according to the Mayo Clinic:

For predicting your risk of heart disease, many doctors now believe that determining your non-HDL cholesterol level may be more useful than calculating your cholesterol ratio.

And either option appears to be a better risk predictor than your total cholesterol level or even your low-density lipoprotein (LDL, or “bad”) cholesterol level. Non-HDL cholesterol, as its name implies, simply subtracts your high-density lipoprotein (HDL, or “good”) cholesterol number from your total cholesterol number. So it contains all the “bad” types of cholesterol.

An optimal level of non-HDL cholesterol is less than 130 milligrams per deciliter (mg/dL), or 3.37 millimoles per liter (mmol/L). Higher numbers mean a higher risk of heart disease.

To calculate your cholesterol ratio, divide your total cholesterol number by your HDL cholesterol number. So if your total cholesterol is 200 mg/dL (5.2 mmol/L) and your HDL is 50 mg/dL (1.3 mmol/L), your ratio would be 4-to-1. Higher ratios mean a higher risk of heart disease.

My HDL level is 65 and my total cholesterol level is 199.

  • 199 / 65 = 3.06

According to available consensus, I have a less than half the risk of a heart attack:

The Framingham Heart Study states that the following cholesterol ratios roughly signal different degrees of heart disease risk:

Men

5.0 = average risk

3.4 = half the average risk

9.6 = twice the average risk

HOWEVER…..

Because I have had my labs measured for years, I see that my LDL levels increased.

2013 cholesterol levels:

  • Total 132
  • Triglycerides 41
  • HDL cholesterol 45
  • VLDL cholesterol 8
  • LDL cholesterol 79

Because I’ve tracked my blood work since 2013, I see that my LDL went up, spiking my total cholesterol level. Basically because I’ve eaten like a fat ass all year while still exercising.

HDL levels go up when you exercise aggressively.

Fasting Glucose

Fasting glucose levels (measured in two ways) are more important that cholesterol levels. Your fasting glucose levels on a blood test will show you your risk for diabetes.

  • Glucose 89 ….. NORMAL 65-99 mg/dL

89 is good, especially as my levels in 2013 were 84.

According to the Mayo Clinic:

  • A fasting blood sugar level less than 100 mg/dL (5.6 mmol/L) is normal. A fasting blood sugar level from 100 to 125 mg/dL (5.6 to 6.9 mmol/L) is considered prediabetes. If it’s 126 mg/dL (7 mmol/L) or higher on two separate tests, you have diabetes.

I also had my Hemoglobin A1c labs done:

  • Hemoglobin A1c 4.9

That’s a freaking good number according to Mayo:

  • Glycated hemoglobin (A1C) test. This blood test, which doesn’t require fasting, indicates your average blood sugar level for the past two to three months. It measures the percentage of blood sugar attached to hemoglobin, the oxygen-carrying protein in red blood cells. The higher your blood sugar levels, the more hemoglobin you’ll have with sugar attached. An A1C level of 6.5 percent or higher on two separate tests indicates that you have diabetes. An A1C between 5.7 and 6.4 percent indicates prediabetes. Below 5.7 is considered normal.

I’ve still cut the carbs down largely because my diet is a disaster as anyone who follows my Instagram knows.

Vitamin D

Vitamin D levels should be in the 50 ng/mL range.

My result was 40.1 ng/mL range.

No big deal, I’ll start taking 5,000 iu’s of Vitamin D a day for a month or two and also make sure to get some more sunshine.

Misc blood work / lab results

Each person is different and your blood will tell the tale.

A full lab shows more than just tesosterone levels, and looks like this:

CBC With Differential/Platelet WBC 5.6 NORMAL 3.4-10.8 x10E3/uL 01 RBC 4.60 NORMAL 4.14-5.80 x10E6/uL 01

Hemoglobin 14.1 NORMAL 13.0-17.7 g/dL 01

Hematocrit 42.4 NORMAL 37.5-51.0 % 01

MCV 92 NORMAL 79-97 fL 01 MCH 30.7 NORMAL 26.6-33.0 pg 01

MCHC 33.3 NORMAL 31.5-35.7 g/dL 01 RDW 13.2 NORMAL 12.3-15.4 % 01

Platelets 286 NORMAL 150-450 x10E3/uL 01 Neutrophils 38 NORMAL Not Estab. % 01

Lymphs 44 NORMAL Not Estab. % 01

Monocytes 14 NORMAL Not Estab. % 01 Eos 3 NORMAL Not Estab. % 01 Basos 0 NORMAL Not Estab. % 01

Neutrophils (Absolute) 2.1 NORMAL 1.4-7.0 x10E3/uL 01

Lymphs (Absolute) 2.5 NORMAL 0.7-3.1 x10E3/uL 01

Monocytes(Absolute) 0.8 NORMAL 0.1-0.9 x10E3/uL 01 Eos (Absolute) 0.2 NORMAL 0.0-0.4 x10E3/uL 01

Baso (Absolute) 0.0 NORMAL 0.0-0.2 x10E3/uL 01

Immature Granulocytes 1 NORMAL Not Estab. % 01

Immature Grans (Abs) 0.0 NORMAL 0.0-0.1 x10E3/uL 01

How to Get Blood Work Done.

I get the Male Anti-Aging Panel from Private MD Labs here.

Past experiences with doctors have shown that they won’t order the full labs, and when they do, they often won’t send you the full records.

I also like that I can log into a dashboard and get all of my blood work for over half a decade.

This is what the dashboard looks like. I have all of my data in one place, and they don’t charge you an annual fee to keep it stored here, unlike many of the new “health apps.”

The Male Anti-Aging Panel is comprehensive and covers every test I mentioned above and a lot more.

I get the Male Anti-Aging Panel done once every 12-18 months, because it’s expensive (your health is worth it), and I get a smaller test done more frequently as needed.

HEALTHY12 usually works as a 12% off coupon code. I used it on my last test and it worked.

What to do about Testosterone Levels.

Go see a doctor who specializes in male hormone optimization. Don’t waste your time with a General Practitioner unless you have a good relationship with him and her and they won’t give you any static.

TRT is around $80 a month.

Now there’s a lot of disinformation about TRT, and my answer is that I don’t care if you go see a doctor about TRT.

Lifting Weights + TRT Saved Arnold Schwarzenegger’s Life

I don’t have all day to hand hold cry babies who believe the lies.

Get your labs done, take care of your health, and talk to a doctor.

And listen to this podcast:

The Complete Guide to Fasting for Fat Loss, Increased Focus, and Spirituality

However also know that most of what you read online about how to “naturally raise testosterone levels” is bullshit as are those over-the-counter “testosterone boosters.”

If you enjoyed this article about men’s health, read Gorilla Mindset, which covers mindset and physical health.

Get Gorilla Mindset here.

Supplements I take for overall Men’s Health

Vasky – a vasodilator.

Vasodilators are medications that open (dilate) blood vessels. They affect the muscles in the walls of your arteries and veins, preventing the muscles from tightening and the walls from narrowing. As a result, blood flows more easily through your vessels. Your heart doesn’t have to pump as hard, reducing your blood pressure.

As the great Dr. Brett Osborn is fond of saying, “You’re only as old as your blood vessels.”

Vasodilators open up your blood vessels, leading to improved circulation. (But you have to see a doctor because you may have bleeding issues and a vasodilator could be harmful!)

Vasodilators also improve blood flow to other parts of the body if you know what I mean.

Vasky Is from MTS Nutrition and you can get it here.

3 cans of sardines a week.

Sardines are loaded with Omega 3 fatty acids, which are good for your heart.

Other people take fish oil, although some evidence suggests the body doesn’t absorb the Omega 3’s from fish oil as well as it does from whole fish. (Some idiot is going to scare monger about mercury and just go away because that’s disinformation and we don’t have time for that here.)

Coenzyme Q10 (CoQ10) is one of the few supplements the straight-laced Mayo Clinic recommends:

Heart conditions. CoQ10 has been shown to improve symptoms of congestive heart failure. Although findings are mixed, CoQ10 might help reduce blood pressure. Some research also suggests that when combined with other nutrients, CoQ10 might aid recovery in people who’ve had bypass and heart valve surgeries. Parkinson’s disease. Early research suggests that high doses of CoQ10 might be beneficial for people in the early stages of this progressive disorder of the nervous system that affects movement.

DHEA

DHEA is less important than testosterone, but it’s still an important male hormone. Some evidence suggests that DHEA is good for bone health.

Magnesium

Magnesium is the most important supplement men (and women) can take.

Read the full fact sheet here:

Magnesium, an abundant mineral in the body, is naturally present in many foods, added to other food products, available as a dietary supplement, and present in some medicines (such as antacids and laxatives). Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. Magnesium is required for energy production, oxidative phosphorylation, and glycolysis. It contributes to the structural development of bone and is required for the synthesis of DNA, RNA, and the antioxidant glutathione. Magnesium also plays a role in the active transport of calcium and potassium ions across cell membranes, a process that is important to nerve impulse conduction, muscle contraction, and normal heart rhythm.

Vitamin D.

Vitamin D is also a must-have supplement. Read the full fact sheet here:

Vitamin D promotes calcium absorption in the gut and maintains adequate serum calcium and phosphate concentrations to enable normal mineralization of bone and to prevent hypocalcemic tetany. It is also needed for bone growth and bone remodeling by osteoblasts and osteoclasts. Without sufficient vitamin D, bones can become thin, brittle, or misshapen. Vitamin D sufficiency prevents rickets in children and osteomalacia in adults. Together with calcium, vitamin D also helps protect older adults from osteoporosis.

Gorilla Mind Smooth.

Gorilla Mind Smooth is a stimulant-free focusing agent.

I take it most days, and sometimes stack it with Rush (as when I need to get a lot of writing done). Get it here.

Books to Read on Men’s Health

I only recommend two, because they are the best.

Get Serious by Dr. Brett Obsorn is the best general book on health and fitness for men.

The Testosterone Optimization Therapy Bible by Jay Campbell is the best book on testosterone and other specialized subjects.

Gorilla Mindset by Mike Cernovich is the best overall book on mindset + good living.

Stay healthy friends!

This article is probably a lot of reading, and yet it’s only part of the knowledge you need to live a full and complete life.

If you have any questions, post them below!

P.S. If you made it this far, you deserve a reward. Use GM10 at checkout to save 10% on your full order at Gorilla Mind here.

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Mindset

Podcast – How to Win Big By Starting Small

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For a while I wanted to start a podcast focusing on a lot of issues you want to know more about, and finding the right people to work with is something I take my time doing.

We already have Jay back with the best health and fitness information you’ll get anywhere.

And Alex and Ed have done seminars with me.

What about the entrepreneurial podcast, though…

I’ve had more failures than successes, and needed someone to balance me out who has had more successes than failures, and also someone who had expertise in areas I didn’t.

(That’s how partnership works. There’s no reason to work with your twin. You partner with people who have complementary skills.)

A guy came down for a cigar night and seemed OK.

I tend to like people right away and work with them, or not.

Sometimes it leads me into some issues (as with my first film), but more often my instincts are right and it pays off.

(I had a bad feeling about the guy I did my first film with, but it was too late at that point.)

He said, “Wanna start a podcast?”

Sure.

And Mindset Squared was created.

What are we going to talk about?

Well Mike brought down a bottle of Pappy Van Winkle’s 23 to compare with Yamazaki 18, so there will be some “good life” stuff for sure.

And also business and other subjects.

You can listen to all of the Mindset Squared episodes here:

You can listen to our most recent episode below:

Or watch the video here:

And bookmark this page to stay updated on all matters podcast related.

Mike Cernovich Podcasts

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Mindset

Listen to the first two chapters of the Gorilla Mindset audiobook for free

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Listen and if you like it, buy it at Audible here.

Gorilla Mindset: Introduction

Gorilla Mindset Chapter 1: Mindset is a Conversation

 

Gorilla Mindset audiobook reviews

Gorilla Mindset has over 1,400 ratings.

  • Essentials of mindset & lifestyle in one book
  • Gorilla Mindset is a series of mindset and lifestyle shifts that you can adopt in your life to get more of what you want. The audiobook helps you take your Gorilla Mindset training to the next level if you are working the paperback/kindle as well.
  • Just what I needed Some really great stuff in here about shifting your mindset from accepting life to doing something about it.
  • Self awareness Loved this book now I can see myself, or be more aware of myself. Thank you Mike.
  • Awesome! Wow! The things we can do when we have our mind focused on dong the right things.
  • A relatable book I’ve met Mike on a couple occasions and respect how he thinks and acts with intention. When I first heard the word mindset I thought some woo woo stuff. It took me some time to realize I was mistaken. I felt this book. It resonates. Try it out.
  • Great read to start a new year off right! Gorilla Mindset was very empowering and gave me a fresh outlook on life. This book started making me feel like I’ve been standing on the sidelines of my own life and that I am capable of so much more. I am ready to put these new ideas into action.
  • You really need this book! This is a fantastic book and is well worth the read. Mike has proven with venture after venture that he knows what he is talking about and is worth listening to. Tons of helpful insights and suggestions here…if you only absorb a small percentage of them, it will still be well worth your time.
  • Listen all the way through You have to listen to all of it. There is good material and ok material throughout, even though there is likely one or more things you won’t agree with or like. It’s only about four hours long and not polished but that makes it worth listening to and real.
  • Amazing and Enlightening ! Everyone should really read this. I completed with no interruptions! Very Detailed!
  • Thought provoking Mike Cernovich brings unique insight to personal development. He’s got advice on mental and physical health as well and relationships.
  • Big Brother Advice You Never Got It’s a great book, full of practical advice and I am going to use it. I never got any direction from my parents or brothers and I’m sure my generation(GenX) as a whole didn’t either. It’s only after much toil, that I have taken a sledgehammer to the poorly self poured foundation that I have haphazardly built. The words spoken in this book are more important now than ever. Thank you for the words of wisdom.
  • open mind Even if you do not agree with all subjects he talks about, it’s a great read/listen and you will walk away learning something new. Maybe even inspired… waiting on G.M.2
  • One of the best if not the greatest book on mindset This book is everything you need to get your mind and body right. With the addition of this audiobook you can hear Mike the same way he delivers on his podcasts. Really glad to have found Cernovich ‘s writing. I’m 110% sure he’s s helped tens of thousands of people all over the world. But this if you need to get your head straight or want more out of life.

You can listen to the full audiobook here.

 

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